Web Service

This web service allows for computation of local ARS profiles of all genes across cell-types as outlined in our publication.

We calculated ARS across 20 different cell-types, considering different genomic segments of DHS volume. These results are searchable via the main interface. It is possible to search by gene-name (HGNC), cell-type and significance thresholds.

Each gene in each genomic segment is represented by a single row containing the following: Gene-name, the actual ARS statistics, angle, cell-type, p-value and q-value. Next to each gene are two options: Plot and Calculate track.

Plot will display the 2D projection of all cell-types, scaled and median centered; with gene expression on the x-axis, and DHS volume on the y-axis. Distinct outlying points are scaled relative to the maximum ARS, thereby indicating the ordering of the genes in terms of likely outliers.

Calculate track will generate a wiggle-track of the local ARS profile. The user is to select which cell-types should be present in the wig-file, but all are used in calculating the actual local ARS values. The generated wig-track can either be downloaded or directly displayed in the UCSC genome browser.

Publication Data

For access to primary data, algorithms etc. used in our publication please click here

View Data