GO Term |
Description |
P-value |
Enrichment (N, B, n, b) |
Genes |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
5.86E-10 |
28.00 (17361,90,62,9) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
ITIH2 - inter-alpha (globulin) inhibitor h2
PZP - pregnancy-zone protein
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
ITIH5 - inter-alpha (globulin) inhibitor h5
ITIH3 - inter-alpha (globulin) inhibitor h3
|
GO:0030414 |
peptidase inhibitor activity |
8.05E-10 |
18.54 (17361,151,62,10) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
GPC3 - glypican 3
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
ITIH2 - inter-alpha (globulin) inhibitor h2
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
PZP - pregnancy-zone protein
ITIH3 - inter-alpha (globulin) inhibitor h3
ITIH5 - inter-alpha (globulin) inhibitor h5
|
GO:0061134 |
peptidase regulator activity |
3.33E-9 |
16.09 (17361,174,62,10) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
GPC3 - glypican 3
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
ITIH2 - inter-alpha (globulin) inhibitor h2
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
PZP - pregnancy-zone protein
ITIH3 - inter-alpha (globulin) inhibitor h3
ITIH5 - inter-alpha (globulin) inhibitor h5
|
GO:0004866 |
endopeptidase inhibitor activity |
8.51E-9 |
12.23 (17361,142,110,11) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
AHSG - alpha-2-hs-glycoprotein
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
SERPINA11 - serpin peptidase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 11
ITIH2 - inter-alpha (globulin) inhibitor h2
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
PZP - pregnancy-zone protein
ITIH3 - inter-alpha (globulin) inhibitor h3
ITIH5 - inter-alpha (globulin) inhibitor h5
|
GO:0061135 |
endopeptidase regulator activity |
8.97E-9 |
12.14 (17361,143,110,11) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
AHSG - alpha-2-hs-glycoprotein
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
SERPINA11 - serpin peptidase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 11
ITIH2 - inter-alpha (globulin) inhibitor h2
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
PZP - pregnancy-zone protein
ITIH3 - inter-alpha (globulin) inhibitor h3
ITIH5 - inter-alpha (globulin) inhibitor h5
|
GO:0004857 |
enzyme inhibitor activity |
1.94E-8 |
11.41 (17361,270,62,11) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
AMBP - alpha-1-microglobulin/bikunin precursor
GPC3 - glypican 3
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
APOC3 - apolipoprotein c-iii
ITIH2 - inter-alpha (globulin) inhibitor h2
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
PZP - pregnancy-zone protein
ITIH3 - inter-alpha (globulin) inhibitor h3
ITIH5 - inter-alpha (globulin) inhibitor h5
|
GO:0070325 |
lipoprotein receptor binding |
2.92E-7 |
406.90 (17361,16,8,3) |
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APOA1 - apolipoprotein a-i
APOB - apolipoprotein b (including ag(x) antigen)
APOC3 - apolipoprotein c-iii
|
GO:0070653 |
high-density lipoprotein receptor binding |
1.1E-6 |
1,446.75 (17361,3,8,2) |
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APOA1 - apolipoprotein a-i
APOC3 - apolipoprotein c-iii
|
GO:0043499 |
eukaryotic cell surface binding |
1.13E-6 |
80.38 (17361,16,54,4) |
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FGG - fibrinogen gamma chain
PCSK6 - proprotein convertase subtilisin/kexin type 6
FGA - fibrinogen alpha chain
FGB - fibrinogen beta chain
|
GO:0031406 |
carboxylic acid binding |
3.73E-6 |
3.60 (17361,144,670,20) |
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PLOD3 - procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
EGLN2 - egl nine homolog 2 (c. elegans)
FFAR1 - free fatty acid receptor 1
HNF4A - hepatocyte nuclear factor 4, alpha
GRIN1 - glutamate receptor, ionotropic, n-methyl d-aspartate 1
NR1H4 - nuclear receptor subfamily 1, group h, member 4
SOAT2 - sterol o-acyltransferase 2
SNCA - synuclein, alpha (non a4 component of amyloid precursor)
ACBD4 - acyl-coenzyme a binding domain containing 4
AGXT - alanine-glyoxylate aminotransferase
NOS3 - nitric oxide synthase 3 (endothelial cell)
PAH - phenylalanine hydroxylase
NDUFAB1 - nadh dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kda
GOT1 - glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
PDHX - pyruvate dehydrogenase complex, component x
ALB - albumin
GLRB - glycine receptor, beta
AZGP1 - alpha-2-glycoprotein 1, zinc-binding
ACOT7 - acyl-coa thioesterase 7
FABP1 - fatty acid binding protein 1, liver
|
GO:0033293 |
monocarboxylic acid binding |
6.03E-6 |
31.57 (17361,55,50,5) |
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ALB - albumin
HNF4A - hepatocyte nuclear factor 4, alpha
NR1H4 - nuclear receptor subfamily 1, group h, member 4
AZGP1 - alpha-2-glycoprotein 1, zinc-binding
FABP1 - fatty acid binding protein 1, liver
|
GO:0005504 |
fatty acid binding |
6.36E-6 |
7.32 (17361,37,641,10) |
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NDUFAB1 - nadh dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kda
ALB - albumin
HNF4A - hepatocyte nuclear factor 4, alpha
FFAR1 - free fatty acid receptor 1
SOAT2 - sterol o-acyltransferase 2
SNCA - synuclein, alpha (non a4 component of amyloid precursor)
ACBD4 - acyl-coenzyme a binding domain containing 4
ACOT7 - acyl-coa thioesterase 7
AZGP1 - alpha-2-glycoprotein 1, zinc-binding
FABP1 - fatty acid binding protein 1, liver
|
GO:0008289 |
lipid binding |
1.54E-5 |
4.65 (17361,408,128,14) |
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HNF4A - hepatocyte nuclear factor 4, alpha
NR1H4 - nuclear receptor subfamily 1, group h, member 4
SOAT2 - sterol o-acyltransferase 2
CHPT1 - choline phosphotransferase 1
APOA1 - apolipoprotein a-i
ALB - albumin
ITPR2 - inositol 1,4,5-triphosphate receptor, type 2
APOB - apolipoprotein b (including ag(x) antigen)
ADH4 - alcohol dehydrogenase 4 (class ii), pi polypeptide
ZCCHC2 - zinc finger, cchc domain containing 2
APOC3 - apolipoprotein c-iii
AZGP1 - alpha-2-glycoprotein 1, zinc-binding
FABP1 - fatty acid binding protein 1, liver
CADPS2 - ca++-dependent secretion activator 2
|
GO:0017127 |
cholesterol transporter activity |
5.29E-5 |
413.36 (17361,12,7,2) |
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APOA1 - apolipoprotein a-i
APOB - apolipoprotein b (including ag(x) antigen)
|
GO:0048037 |
cofactor binding |
6.01E-5 |
3.80 (17361,251,273,15) |
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SOAT2 - sterol o-acyltransferase 2
GPT2 - glutamic pyruvate transaminase (alanine aminotransferase) 2
FMO5 - flavin containing monooxygenase 5
HAO2 - hydroxyacid oxidase 2 (long chain)
ACOX1 - acyl-coenzyme a oxidase 1, palmitoyl
ABAT - 4-aminobutyrate aminotransferase
AGXT - alanine-glyoxylate aminotransferase
ALDH1A3 - aldehyde dehydrogenase 1 family, member a3
UGDH - udp-glucose dehydrogenase
PAH - phenylalanine hydroxylase
IDH3B - isocitrate dehydrogenase 3 (nad+) beta
ALB - albumin
POR - p450 (cytochrome) oxidoreductase
ADH4 - alcohol dehydrogenase 4 (class ii), pi polypeptide
PSAT1 - phosphoserine aminotransferase 1
|
GO:0015248 |
sterol transporter activity |
6.61E-5 |
381.56 (17361,13,7,2) |
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APOA1 - apolipoprotein a-i
APOB - apolipoprotein b (including ag(x) antigen)
|
GO:0030234 |
enzyme regulator activity |
7.3E-5 |
2.89 (17361,846,156,22) |
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A2M - alpha-2-macroglobulin
ITIH1 - inter-alpha (globulin) inhibitor h1
SERGEF - secretion regulating guanine nucleotide exchange factor
GPC3 - glypican 3
AHSG - alpha-2-hs-glycoprotein
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
IKBKAP - inhibitor of kappa light polypeptide gene enhancer in b-cells, kinase complex-associated protein
SERPINA11 - serpin peptidase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 11
VAV2 - vav 2 guanine nucleotide exchange factor
PZP - pregnancy-zone protein
SERPIND1 - serpin peptidase inhibitor, clade d (heparin cofactor), member 1
APOA1 - apolipoprotein a-i
AMBP - alpha-1-microglobulin/bikunin precursor
GCKR - glucokinase (hexokinase 4) regulator
TBC1D4 - tbc1 domain family, member 4
CAMK2N1 - calcium/calmodulin-dependent protein kinase ii inhibitor 1
CHN2 - chimerin (chimaerin) 2
MMP15 - matrix metallopeptidase 15 (membrane-inserted)
APOC3 - apolipoprotein c-iii
ITIH2 - inter-alpha (globulin) inhibitor h2
ITIH5 - inter-alpha (globulin) inhibitor h5
ITIH3 - inter-alpha (globulin) inhibitor h3
|
GO:0008483 |
transaminase activity |
7.89E-5 |
16.40 (17361,21,252,5) |
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AMT - aminomethyltransferase
GPT2 - glutamic pyruvate transaminase (alanine aminotransferase) 2
PSAT1 - phosphoserine aminotransferase 1
AGXT - alanine-glyoxylate aminotransferase
ABAT - 4-aminobutyrate aminotransferase
|
GO:0043498 |
cell surface binding |
8.37E-5 |
30.62 (17361,42,54,4) |
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FGG - fibrinogen gamma chain
PCSK6 - proprotein convertase subtilisin/kexin type 6
FGA - fibrinogen alpha chain
FGB - fibrinogen beta chain
|
GO:0031703 |
type 2 angiotensin receptor binding |
1.73E-4 |
5,787.00 (17361,1,3,1) |
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AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
|
GO:0015485 |
cholesterol binding |
1.87E-4 |
241.12 (17361,18,8,2) |
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APOA1 - apolipoprotein a-i
APOC3 - apolipoprotein c-iii
|
GO:0005543 |
phospholipid binding |
2.85E-4 |
34.27 (17361,190,8,3) |
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APOA1 - apolipoprotein a-i
APOB - apolipoprotein b (including ag(x) antigen)
APOC3 - apolipoprotein c-iii
|
GO:0046904 |
calcium oxalate binding |
2.88E-4 |
3,472.20 (17361,1,5,1) |
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AMBP - alpha-1-microglobulin/bikunin precursor
|
GO:0034191 |
apolipoprotein A-I receptor binding |
3.46E-4 |
2,893.50 (17361,1,6,1) |
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APOA1 - apolipoprotein a-i
|
GO:0005496 |
steroid binding |
3.46E-4 |
21.70 (17361,64,50,4) |
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APOA1 - apolipoprotein a-i
NR1H4 - nuclear receptor subfamily 1, group h, member 4
APOC3 - apolipoprotein c-iii
FABP1 - fatty acid binding protein 1, liver
|
GO:0016769 |
transferase activity, transferring nitrogenous groups |
3.74E-4 |
4.95 (17361,30,1053,9) |
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SPTLC2 - serine palmitoyltransferase, long chain base subunit 2
AMT - aminomethyltransferase
AGXT2L2 - alanine-glyoxylate aminotransferase 2-like 2
GOT1 - glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
GPT2 - glutamic pyruvate transaminase (alanine aminotransferase) 2
BCAT2 - branched chain aminotransferase 2, mitochondrial
PSAT1 - phosphoserine aminotransferase 1
AGXT - alanine-glyoxylate aminotransferase
ABAT - 4-aminobutyrate aminotransferase
|
GO:0032934 |
sterol binding |
3.88E-4 |
173.61 (17361,25,8,2) |
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APOA1 - apolipoprotein a-i
APOC3 - apolipoprotein c-iii
|
GO:0004528 |
phosphodiesterase I activity |
3.89E-4 |
103.34 (17361,4,84,2) |
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ENPP3 - ectonucleotide pyrophosphatase/phosphodiesterase 3
ENPP1 - ectonucleotide pyrophosphatase/phosphodiesterase 1
|
GO:0032052 |
bile acid binding |
4.36E-4 |
115.74 (17361,6,50,2) |
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NR1H4 - nuclear receptor subfamily 1, group h, member 4
FABP1 - fatty acid binding protein 1, liver
|
GO:0019959 |
interleukin-8 binding |
5.05E-4 |
5,787.00 (17361,3,1,1) |
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A2M - alpha-2-macroglobulin
|
GO:0005102 |
receptor binding |
5.22E-4 |
3.21 (17361,911,89,15) |
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FGG - fibrinogen gamma chain
DOK6 - docking protein 6
HNF4A - hepatocyte nuclear factor 4, alpha
FGL1 - fibrinogen-like 1
NR1H4 - nuclear receptor subfamily 1, group h, member 4
PROX1 - prospero homeobox 1
AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
VAV2 - vav 2 guanine nucleotide exchange factor
APOA1 - apolipoprotein a-i
SLC2A2 - solute carrier family 2 (facilitated glucose transporter), member 2
APOB - apolipoprotein b (including ag(x) antigen)
ENPP1 - ectonucleotide pyrophosphatase/phosphodiesterase 1
FGA - fibrinogen alpha chain
FGB - fibrinogen beta chain
APOC3 - apolipoprotein c-iii
|
GO:0010698 |
acetyltransferase activator activity |
5.71E-4 |
2,893.50 (17361,2,3,1) |
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AGT - angiotensinogen (serpin peptidase inhibitor, clade a, member 8)
|
GO:0047963 |
glycine N-choloyltransferase activity |
7.49E-4 |
1,335.46 (17361,1,13,1) |
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BAAT - bile acid coenzyme a: amino acid n-acyltransferase (glycine n-choloyltransferase)
|
GO:0005319 |
lipid transporter activity |
9.42E-4 |
33.39 (17361,65,24,3) |
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APOA1 - apolipoprotein a-i
APOB - apolipoprotein b (including ag(x) antigen)
FABP1 - fatty acid binding protein 1, liver
|
The system has recognized 34219 genes out of 34248 gene terms entered by the user.
34219 genes were recognized by gene symbol and 0 genes by other gene IDs .
12742 duplicate genes were removed (keeping the highest ranking instance of each gene) leaving a total of 21477 genes
Only 17361 of these genes are associated with a GO term
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